I like the idea of using gene therapy in the treatment of devastating diseases. I especially find interesting the use of a vector to deliver therapeutic genetic information into a cell. It seems like a very sophisticated and clever way to trick the trickster.
However, this interesting method also makes me concerned. I get distracted by the replication process that is inherent to viral activity. We are essentially manipulating a pathogenic process and using that process to reverse disease. But what if you get too much of a good thing? Perhaps I am too swept away by the science fictional aspects of this idea- but what if that specific virus you manipulate somehow goes rogue and gets into the general population and replicates itself? Does it still maintain its therapeutic effect? Or would it then just be messing with perfectly healthy genes? What if the vehicle for good goes bad? How is this process contained/controlled? Lotsa questions.
Perhaps what is underlying my concern is the thought of scientists’ manipulating genes in a way that would never happen in nature. It sort of reminds me of GMO food. The argument on the pro-GMO side was that it would enable farmers to grow robust crops and we could feed a large population. The picture that was painted for us was in the vein of Monsanto’s “Golden Rice.” We are going to feed the world! They proclaimed. There were images of starving children shown to us, a way to proclaim that humanitarianism was the premise for Monsanto's endeavours. On the other side, people argued that these manipulations would never occur naturally and we have no idea what the health effects would be nor could we know the consequences of introducing GMO strains into the worldwide food population. So, here we are today with reports of health problems related to GMO food and not a single bit of corn on the planet that has been untainted by this process.
That said, I hope this process goes forward carefully and consciously. I understand that the manipulation of genetic material is a next step in fighting disease and I would love to see some effective therapies come out of this process. I just think we need to keep a critical eye on how the process unfolds.